Not known Facts About Promethazine codeine syrup
Not known Facts About Promethazine codeine syrup
Blog Article
It's hard to decide what constitutes a standard poisonous or lethal dose. Even so, the lethal oral dose of codeine within an Grownup is noted being within the range of 0.
If the patient develops these symptoms or signs or symptoms, elevate the dose to your preceding amount and taper additional gradually, either by escalating the interval among decreases, lowering the level of transform in dose, or both.
Lifetime-threatening respiratory complications (respiratory melancholy). Promethazine Hydrochloride and Codeine Phosphate Oral Remedy can result in respiratory complications (respiratory despair) that may come about at any time through treatment and may lead to Demise. Your risk of respiratory difficulties is best if you initial commence taking Promethazine Hydrochloride and Codeine Phosphate Oral Resolution, are taking other medicines that can result in respiratory difficulties, have particular lung difficulties, are aged or have selected other health problems.
The concomitant usage of Promethazine HCl and Codeine Phosphate Oral Alternative with all cytochrome P450 3A4 inducers or discontinuation of the cytochrome P450 3A4 inhibitor may well result in lessen codeine stages, better norcodeine stages, and fewer metabolism by way of 2D6 with resultant reduce morphine levels.
Promethazine ought to be utilized with caution in sufferers with bone marrow depression. Leukopenia and agranulocytosis are already described, generally when promethazine HCl is used in Affiliation with other acknowledged marrow-toxic brokers.
The mixture of promethazine hydrochloride and codeine phosphate is contraindicated in pediatric individuals a lot less than 6 years of age.
From Mayo Clinic to your inbox Enroll in absolutely free and keep updated on investigation developments, wellbeing tips, present-day well being subject areas, and know-how on handling wellbeing. Click here for an e mail preview.
The phosphate salt of codeine happens as white, needle-formed crystals or white crystalline powder. Codeine phosphate is freely soluble in h2o and a little soluble in Alcoholic beverages. The molecular weight is 406.37. Its molecular system is C18H21NO3•H3PO4 • ½ H2O, and it's the next chemical composition.
Warning patients that some folks have a variation inside a liver enzyme and Promethazine codeine syrup change codeine into morphine a lot more fast and entirely than Other individuals. These men and women are extremely-speedy metabolizers and usually tend to have higher-than-regular levels of morphine inside their blood soon after using codeine which may lead to overdose signs for example Excessive sleepiness, confusion, or shallow respiratory. In most cases, it can be not known if a person is surely an ultra-immediate codeine metabolizer.
If this SPL is made up of inactivated NDCs detailed by the FDA initiated compliance action, They are going to be specified therefore.
Get this medication just as prescribed to lessen the risk of dependancy. Request your medical professional or pharmacist For additional information.
This merchandise may comprise inactive elements, which could cause allergic reactions or other complications. Talk with your pharmacist for more aspects.
Narcotic analgesics or cough suppressants, such as codeine, shouldn't be Employed in asthmatic patients (see CONTRAINDICATIONS). Nor ought to they be used in acute febrile ailment linked to productive cough or in Continual respiratory illness in which interference with capacity to very clear the tracheobronchial tree of secretions would've a deleterious impact on the client's respiratory function.
Promethazine HCl and Codeine Phosphate Oral Solution could induce extreme hypotension which include orthostatic hypotension and syncope in ambulatory clients. There's increased danger in clients whose skill to take care of blood pressure level has by now been compromised by a reduced blood volume or concurrent administration of particular CNS depressant medicines (e.